Chromatin organization, structure and dynamics
نویسندگان
چکیده
منابع مشابه
Nuclear visions enhanced: chromatin structure, organization and dynamics.
The EMBO Workshop on 'Chromatin Structure, Organization and Dynamics' took place in April 2011 in Prague, Czech Republic. Scientists from the life sciences, chemistry and biophysics presented their latest data on the generation of three-dimensional and, eventually, four-dimensional models of the genome, working to correlate changes in the organization of chromatin with the functional state of t...
متن کاملOrganization of DNA in chromatin ( chromatin structure / intercalation / DNA - kinking )
Conformational changes in DNA that accompany drug intercalation have led us to ask if DNA first bends or "kinks" to accept an intercalative drug or dye. Kinking is made possible by altering the normal C2' endo deoxyribose sugar ring puckering in B DNA to a mixed sugarpuckering pattern of the type C3' endo (3'-5') C2' endo and partially unstacking base-pairs. A kinking scheme such as this would ...
متن کاملChromatin Structure in Telomere Dynamics
The establishment of a specific nucleoprotein structure, the telomere, is required to ensure the protection of chromosome ends from being recognized as DNA damage sites. Telomere shortening below a critical length triggers a DNA damage response that leads to replicative senescence. In normal human somatic cells, characterized by telomere shortening with each cell division, telomere uncapping is...
متن کاملChromatin higher-order structure and dynamics.
The primary role of the nucleus as an information storage, retrieval, and replication site requires the physical organization and compaction of meters of DNA. Although it has been clear for many years that nucleosomes constitute the first level of chromatin compaction, this contributes a relatively small fraction of the condensation needed to fit the typical genome into an interphase nucleus or...
متن کاملStructure and dynamics of transcriptionally active chromatin.
Chromatin is a highly dynamic macromolecular complex that undergoes continuous structural modification during the various stages of genetic activity. Such dynamic behavior is the result of a complex and perfectly balanced network of interactions involving histones, DNA and ions in an aqueous environment. In the past eighteen years since the discovery of the nucleosome particle, a great deal of ...
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ژورنال
عنوان ژورنال: Nucleus
سال: 2011
ISSN: 1949-1034,1949-1042
DOI: 10.4161/nucl.2.5.17858